TABLE 5.

Noncompartmental pharmacokinetic parameters for R (+) Ketorolac and S (−) Ketorolac

	R (+) Ketorolac	S (−) Ketorolac	Probability
Cmax (µg/ml)
0.5 mg/kg (n=10)	2.5 ± 1.4	1.1 ± 0.6	P=0.014
1.0 mg/kg (n=20)	4.1 ±1.8	2.0 ± 1.1	P= 0.001
AUC (µg/ml/min)
0.5 mg/kg (n=10)	375 ± 224	75 ± 26	P=0.0024
1.0 (mg/kg (n=20)	711 ± 612	183 ± 167	P=0.0013
Cl (ml/min/kg)	0.95 ± 0.54	5.1 ± 4.3	P< 0.001
Vβ (L/kg)	0.27 ± 0.17	0.45 ± 0.33	P=0.006
T½ β (min)	197 ± 82	67 ± 33	P < 0.001