Figure 2. NSAIDs inhibit PGE2 production in human colon cancer cells.
SW480 (A) and DLD-1 (B) human colon cancer cell lines were treated with a panel of NSAIDs (S-ibuprofen, aspirin, sulindac sulfide, sulindac sulfone and indomethacin) for 24 hours as described under Materials and Methods. At the end of drug treatment, supernatants were collected and PGE2 levels were determined by ELISA. Columns, mean of three samples per group; bars, SE. *, P = 0.0008 for A and 0.033 for B, ANOVA between groups.