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. 2011 Jan 13;90(2):305–314. doi: 10.1093/cvr/cvr007

Figure 4.

Figure 4

Knockdown of AhR in H9C2 cells decreases AhR expression and inhibits the upregulation of CYP1A1 and GSTA1 in response to DOX. (A) Effects of scrambled (Scr) and anti-AhR siRNA on whole cell expression of AhR. (B) Effect of scrambled (Scr) and anti-AhR siRNA on the expression of AhR both in the cytosol and nucleus and the response to 4 or 24 h of treatment with 2.5 µM DOX (n = 4 for all groups). (C) Changes in CYP1A1 and GSTA1 expression in H9C2 cells following knockdown of AhR expression and treatment with 2.5 µM DOX for 4 or 24 h (n = 4 for all groups). *P < 0.05 compared with scrambled siRNA.