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. 2011 Jan 13;90(2):305–314. doi: 10.1093/cvr/cvr007

Figure 5.

Figure 5

Pharmacological inhibition of AhR in ARVM blocks both the nuclear translocation of AhR and the increase in CYP1A1 and GSTA1 in response to DOX. (A) Effects of CH-223191 on the translocation of AhR to the nucleus following treatment with 2.5 µM DOX for 4 or 24 h (n = 4 for all groups). (B) Quantitative PCR analysis of the effects of AhR inhibition by CH-223191 on induction of CYP1A1 and GSTA1 expression by treatment with 2.5 µM DOX for 4 or 24 h (B, n = 4 for all groups). *P < 0.05 compared with control value, †P < 0.05 compared with dimethyl sulfoxide group.