Table 2.
Relationship between BCL-2 (-938C > A) polymorphism and known clinicopathological variables
| Clinicopathological Variables | All | Genotype (%) | Adjusted a | ||
|---|---|---|---|---|---|
| AA | AC+CC | p value | OR | ||
| Age | |||||
| ≤ 40 | 21(18.9) | 3(14.3) | 18(85.7) | 1.00 | |
| > 40 | 90(81.1) | 15(16.7) | 75(83.3) | 0.790 | 1.20 |
| Pathological diagnosis | |||||
| Ductal | 87(76.3) | 14(16.1) | 73(83.9) | 1.00 | |
| Lobular | 7(6.1) | 3(42.9) | 4(57.1) | 0.036 | 6.42 |
| Others | 20(17.6) | 2(10.0) | 18(90.0) | 0.605 | 0.66 |
| Tumor size(cm) | |||||
| ≤ 2 | 50(53.2) | 9(18.0) | 41(82.0) | 1.00 | |
| > 2 | 44(46.8) | 9(20.4) | 35(79.6) | 0.704 | 1.23 |
| Grade | |||||
| I, II | 59(79.7) | 10(16.9) | 49(83.1) | 1.00 | |
| III | 15(20.3) | 2(13.3) | 13(86.7) | 0.725 | 0.74 |
| Positive lymph node | |||||
| 0 | 34(44.7) | 3(8.8) | 31(91.2) | 1.00 | |
| 1-3 | 25(32.9) | 3(12.0) | 22(88.0) | 0.672 | 1.44 |
| ≥ 4 | 17(22.4) | 7(41.2) | 10(58.8) | 0.014 | 6.95 |
| ER | |||||
| Negative | 28(26.9) | 6(21.4) | 22(78.6) | 1.00 | |
| Positive | 76(73.1) | 12(15.8) | 64(84.2) | 0.493 | 0.68 |
| PR | |||||
| Negative | 37(35.9) | 8(21.6) | 29(78.4) | 1.00 | |
| Positive | 66(64.1) | 10(15.2) | 56(84.8) | 0.688 | 0.80 |
| Receptor status | |||||
| Negative | 26(25.2) | 6(23.1) | 20(76.9) | 1.00 | |
| Positive | 77(74.8) | 12(15.6) | 65(84.4) | 0.115 | 3.06 |
| c-erbB2 | |||||
| Negative | 73(70.2) | 13(17.8) | 60(82.2) | 1.00 | |
| Positive | 31(29.8) | 5(16.1) | 26(83.9) | 0.936 | 1.05 |
| Triple-negative | |||||
| No | 87(84.5) | 14(16.1) | 73(83.9) | 1.00 | |
| Yes | 16(15.5) | 4(25.0) | 12(75.0) | 0.444 | 1.67 |
| Ki67 | |||||
| Negative | 59(58.4) | 10(16.9) | 49(83.1) | 0.875 | 1.00 |
| Positive | 42(41.6) | 7(16.7) | 35(83.3) | 1.09 | |
aLogistic regression model adjusted for diagnostic age.
All statistical tests were two-sided with a significance level of p ≤ 0.05.