Table 3.
Gene Ontology categories significantly enriched with differentially expressed genes
| GO Category | Total genes on array |
Changed genes |
Enrichment | FDR |
|---|---|---|---|---|
| Biological Process | ||||
| HEART | ||||
| Translation (GO:0006412) | 319 | 32↑ | 3.334 | <0.001 |
| LIVER | ||||
| Fatty acid beta-oxidation (GO:0006635) | 22 | 5↑ | 6.805 | 0.036 |
| Translation (GO:0006412) | 266 | 28↑ | 3.152 | <0.001 |
| Amino acid catabolic process (GO:0009063) | 36 | 12↓ | 10.202 | <0.001 |
| Cholesterol metabolic process (GO:0008203) | 34 | 7↓ | 5.951 | <0.001 |
| Cellular respiration (GO:0045333) | 47 | 7↓ | 4.559 | 0.024 |
| Molecular Function | ||||
| HEART | ||||
| RNA Binding (GO:0003723) | 455 | 35↑ | 2.500 | <0.001 |
| LIVER | ||||
| RNA Binding (GO:0003723) | 362 | 28↑ | 2.326 | <0.001 |
| Transaminase activity (GO:0008483) | 10 | 5↓ | 15.468 | 0.001 |
| Oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903) | 20 | 6↓ | 9.281 | 0.001 |
| Monooxygenase activity (GO:0004497) | 27 | 7↓ | 8.020 | 0.001 |
| Electron carrier activity (GO:0009055) | 98 | 11↓ | 3.472 | 0.003 |
Arrows indicate direction of gene regulation in hibernating black bears. FDR is false discovery rate.