Table 4.
Genes in significant Gene Ontology categories of the biological processes
| GO category | Gene Name | Gene Symbol |
P value | Fold Change (Log2FC) |
|---|---|---|---|---|
| HEART | ||||
| Up-regulated | ||||
| Translation (GO:0006412) | RNA binding motif protein 3 | Rbm3 | <0.001 | 2.863 |
| Ribosomal protein L35A | Rpl35a | <0.001 | 1.857 | |
| Ribosomal protein S23 | Rps23 | 0.001 | 1.793 | |
| Ribosomal protein L7A | Rpl7a | 0.002 | 1.287 | |
| Ribosomal protein L7 | Rpl7 | <0.001 | 1.243 | |
| Eukaryotic translation elongation factor 1 beta 2 | Eef1b2 | 0.001 | 1.187 | |
| Ribosomal protein S3 | Rps3 | 0.005 | 1.166 | |
| Ribosomal protein L10A | Rpl10a | 0.003 | 1.156 | |
| Eukaryotic translation initiation factor 5A | Eif5a | <0.001 | 1.147 | |
| Ribosomal protein S15A | Rps15a | 0.008 | 1.116 | |
| Ribosomal protein L27 | Rpl27 | 0.003 | 1.099 | |
| Lysyl-trna synthetase | Kars | <0.001 | 1.075 | |
| Ribosomal protein S4, X-linked | Rps4x | 0.001 | 1.018 | |
| Ribosomal protein S13 | Rps13 | 0.003 | 1.012 | |
| Ribosomal protein L30 | Rpl30 | 0.002 | 1.010 | |
| Ribosomal protein S24 | Rps24 | 0.002 | 1.000 | |
| Ribosomal protein, large, P0 | Rplp0 | 0.001 | 0.936 | |
| Ribosomal protein L27A | Rpl27a | 0.008 | 0.927 | |
| Ribosomal protein L22 | Rpl22 | 0.004 | 0.923 | |
| Ribosomal protein L36A-like | Rpl36al | 0.005 | 0.917 | |
| Ubiquitin A-52 residue ribosomal protein fusion product 1 | Uba52 | 0.009 | 0.915 | |
| Eukaryotic translation initiation factor 3, subunit G | Eif3g | 0.001 | 0.910 | |
| Ribosomal protein L5 | Rpl5 | 0.002 | 0.900 | |
| Eukaryotic translation initiation factor 3, subunit F | Eif3f | 0.003 | 0.884 | |
| Ribosomal protein L10A | Rpl10 | 0.008 | 0.863 | |
| Alanyl-trna synthetase domain containing 1 | Aarsd1 | 0.006 | 0.838 | |
| Ribosomal protein, large, P2 | Rplp2 | 0.001 | 0.732 | |
| Ribosomal protein L24 | Rpl24 | 0.003 | 0.725 | |
| Ribosomal protein S27 | Rps27 | 0.001 | 0.720 | |
| Eukaryotic translation initiation factor 2, subunit 3 gamma | Eif2s3 | 0.004 | 0.668 | |
| Density-regulated protein | Denr | 0.007 | 0.651 | |
| Ribosomal protein L18A | Rpl18a | 0.002 | 0.607 | |
| LIVER | ||||
| Up-regulated | ||||
| Fatty acid beta-oxidation (GO:0006635) | Acyl-Coenzyme A dehydrogenase, short/branched chain | Acadsb | 0.010 | 0.922 |
| Acyl-Coenzyme A dehydrogenase, very long chain | Acadvl | 0.001 | 0.842 | |
| Hydroxyacyl-Coenzyme A dehydrogenase, beta subunit | Hadhb | 0.008 | 0.711 | |
| Hydroxyacyl-Coenzyme A dehydrogenase, alpha subunit | Hadha | 0.007 | 0.586 | |
| Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | Acadm | 0.001 | 0.510 | |
| Translation (GO:0006412) | Ribosomal protein L36 | Rpl36 | 0.004 | 1.223 |
| Ribosomal protein L23 | Rpl23 | 0.003 | 1.002 | |
| Nascent polypeptide-associated complex alpha subunit | Naca | 0.001 | 1.182 | |
| Eukaryotic translation elongation factor 1 delta | Eef1d | 0.001 | 1.170 | |
| Translocated promoter region (to activated MET oncogene) | Tpr | <0.001 | 1.116 | |
| Ribosomal protein S6 | Rps6 | 0.010 | 1.079 | |
| Ribosomal protein S20 | Rps20 | 0.002 | 0.990 | |
| Ribosomal protein L34 | Rpl34 | <0.001 | 0.929 | |
| Ribosomal protein L9 | Rpl9 | 0.005 | 0.829 | |
| Ribosomal protein S16 | Rps16 | 0.001 | 0.808 | |
| Mediator complex subunit 8 | Med8 | 0.004 | 0.683 | |
| Ribosomal protein L28 | Rpl28 | 0.001 | 0.617 | |
| Protein kinase C, alpha | Prkca | 0.004 | 0.572 | |
| Isoleucyl-trna synthetase | Iars | 0.007 | 0.565 | |
| Down-regulated | ||||
| Amino acid catabolic process (GO:0009063) | Arginase, liver | Arg1 | 0.009 | -2.050 |
| Glutamic-oxaloacetic transaminase 1, soluble | Got1 | 0.003 | -1.287 | |
| Coenzyme A carboxylase, beta polypeptide | Pccb | <0.001 | -1.176 | |
| Aldehyde dehydrogenase 6 family, member A1 | Aldh6a1 | 0.006 | -1.086 | |
| Methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | Mccc2 | 0.001 | -1.052 | |
| Leucine aminopeptidase 3 | Lap3 | 0.008 | -0.943 | |
| Branched chain keto acid dehydrogenase E1, beta | Bckdhb | <0.001 | -0.937 | |
| Glutamic-oxaloacetic transaminase 2, mitochondrial | Got2 | 0.001 | -0.819 | |
| Aminoadipate aminotransferase | Aadat | 0.008 | -0.812 | |
| Indoleamine 2,3-dioxygenase 2 | Indol1 | 0.003 | -0.810 | |
| Yippee-like 5 | Ypel5 | <0.001 | -0.670 | |
| 3-hydroxyisobutyryl-Coenzyme A hydrolase | Hibch | 0.004 | -0.657 | |
| Cholesterol metabolic process (GO:0008203) | Cytochrome P450, family 7, subfamily a, polypeptide 1 | Cyp7a1 | 0.001 | -2.838 |
| Farnesyl diphosphate synthase) | Fdps | <0.001 | -1.204 | |
| Acetyl-Coenzyme A acetyltransferase 2 | Acat2 | 0.001 | -1.166 | |
| Cytochrome P450, family 27, subfamily A, polypeptide 1 | Cyp27a1 | 0.001 | -1.082 | |
| Paraoxonase 1 | Pon1 | 0.005 | -0.708 | |
| 7-dehydrocholesterol reductase | Dhcr7 | 0.001 | -0.658 | |
| Emopamil binding protein ( | Ebp | 0.020 | -0.463 | |
| Cellular respiration (GO:0045333) | Cytochrome c, somatic | Cycs | 0.002 | -1.139 |
| Mitochondrial ribosomal protein S35 | Mrps35 | 0.004 | -0.859 | |
| Coenzyme Q5 homolog, methyltransferase | Coq5 | 0.001 | -0.783 | |
| NADH dehydrogenase (ubiquinone) Fe-S protein 1 | Ndufs1 | 0.003 | -0.640 | |
| Aconitase 1 | Aco1 | 0.001 | -0.627 | |
| Succinate dehydrogenase complex, subunit C | Sdhc | 0.004 | -0.617 | |
| Pyruvate dehydrogenase (lipoamide) beta | Pdhb | 0.008 | -0.558 | |
Symbols of genes changed in both liver and muscle are in bold.