Table 1.
Monotherapy data on the efficacy of agents and classes of agents in different phases of bipolar illness
| Agent/modality (alphabetical order) | Acute mania | Acute bipolar depression | Maintenance against mania | Maintenance against depression |
|---|---|---|---|---|
| FGAs | Class effect | Unknown | Uncertain class effect | Unknown |
| Chlorpromazine | Positive | - | - | - |
| Haloperidol | Positive | - | - | - |
| Perphenazine | - | - | Negative | - |
| SGAs | Class effect | No class effect | Class effect | No class effect |
| Amisulpride | - | - | - | - |
| Aripiprazole | Positive | Negative | Positive | Negative |
| Asenapine | Positive | - | - | - |
| Clozapine | Positive | - | - | - |
| Olanzapine | Positive | Equivocal | Positive | Positive |
| Olanzapine-fluoxetine combination | - | Positive | - | - |
| Paliperidone | Positive | - | - | - |
| Quetiapine | Positive | Positive | Positive | Positive |
| Risperidone | Positive | - | Positive | - |
| Ziprasidone | Positive | - | Positive | - |
| Antiepileptics | No class effect | No class effect | No class effect | No class effect |
| Carbamazepine | Positive | Equivocal | Equivocal | Equivocal |
| Gabapentin | Negative | - | - | - |
| Lamotrigine | Negative | Negative | Negative | Positive |
| Licarbazepine | Negative | - | - | - |
| Topiramate | Negative | - | - | - |
| Valproate | Positive | Equivocal | Equivocal | Equivocal |
| Antidepressants | Unknown | No class effect | Unknown | No class effect |
| Fluoxetine | - | Positive | - | Positive |
| Paroxetine | - | Negative | - | - |
| Venlafaxine | - | Equivocal | - | - |
- = No data available.