Table 1. Stereological data for betaglycan wildtype, heterozygous and knockout mouse kidneys at e13.5 and e15.5.
+/+ | +/− | −/− | p | ||
e13.5 | Vkid (mm3) | 0.109±0.018a | 0.103±0.021a | 0.077±0.011b | <0.001 |
Vue (mm3) | 0.015±0.003a | 0.015±0.003a | 0.010±0.001b | 0.0013 | |
% Vue of Vkid | 13.50±1.67a | 13.56±0.39a | 12.58±0.26a | 0.3 | |
e15.5 | Vkid (mm3) | 0.261±0.034a | 0.340±0.055b | 0.187±0.005c | <0.001 |
No. of PNA+ve Structures | 68±11a | 90±12b | 47±8 c | <0.001 |
Values are mean ± S.D. e13.5: (n) = +/+ (5), +/− (9), −/− (6); e15.5: (n) = 7 mice/genotype. Data were analysed via one-way ANOVA followed by a Tukey's post-hoc analysis. Those groups not sharing a common letter are significantly different (p<0.01).