Skip to main content
. 2011 Apr 18;6(4):e18816. doi: 10.1371/journal.pone.0018816

Table 3. Percentages of responsive genes modulated by PPAR agonists in primary human hepatocytes and in HepaRG cells.

Compound Concentration (µM) Common modulated genes (%)
Primary human hepatocytes HepaRG cells
Number of donors Number of passages
1 2 3 4 1 2 3
TRO 5 100.0 30.4 4.2 0.3 100.0 27.1 13.4
20 100.0 37.6 5.9 0.8 100.0 33.4 14.7
40 100.0 56.2 31.3
ROSI 50 100.0 21.2 7.2 2.5 100.0 44.4 24.4
100 100.0 39.8 16.4 5.4 100.0 57.4 32.0
150 100.0 52.4 27.7 11.4 100.0 68.4 45.9
MURA 50 100.0 33.8 9.5 2.5 100.0 36.5 17.6
100 100.0 45.9 20.3 6.0 100.0 53.9 30.1
150 100.0 64.8 37.2 14.3 100.0 75.8 58.7
TESA 300 100.0 37.7 9.2 2.5 100.0 36.2 16.3

Percentages of responsive genes modulated by PPAR agonists in primary human hepatocytes from one to four donors and in one to three passages of HepaRG cells.