Table 1. Thermodynamic analysis of DYNLL-binding interactions.
Partner | Kd (µM) | ΔH (kJ mol−1) | -TΔS (kJ mol−1) |
Ac-DKSTQTD | 5.6 | −48.8 | 18.9 |
Ac-GDKSTQTD | 0.56 | −70.3 | 34.4 |
Ac-VDKSTQTD | 0.07 | −65.4 | 24.8 |
dimeric-GSGDKSTQTD* | <0.007 | −76.2 | <29.4 |
dimeric-GSVDKSTQTD* | <0.009 | −88 | <42.0 |
Ac-SRGTQTE | 15.2 | −48.6 | 21.0 |
Ac-GSRGTQTE | 1.64 | −69.7 | 36.5 |
Ac-VSRGTQTE | 0.08 | −75.6 | 35.0 |
dimeric-GSGSRGTQTE* | <0.003 | −69.6 | <20.6 |
dimeric-GSVSRGTQTE* | <0.007 | −64.9 | <17.6 |
EML3 (8-94) | 0.05 | −32.4 | 9.465 |
*Data reach the dynamic range limit of the ITC method.