Proposed points of p53-dependent regulation of the sphingolipid pathway after cell stress. DDR: DNA Damage Response, ARF: Alternate Reading Frame product, ATM: Ataxia Telangiectasia Mutated protein, ATR: Ataxia Telangiectasia and Rad3-related protein, p53: Tumor Suppressor Protein p53, SMase: Sphingomyelinase, SK1: Sphingosine Kinase 1, Cer: Ceramide, and S1P: Sphingosine-1-Phosphate.