Table 1.

Summary of agents that are capable of ameliorating effects of unchecked mGluR5 signaling

Agent	Mode of Action	Animal	Effect	Reference
MPEP	mGluR5 inhibitor	Mouse	Correction of PPI	DeVrij et al., 2008
			Reduction of dendritic protrusions	DeVrij et al., 2008
			Repression of seizures	Westmark et al., 2009
			Rescue of open field behavior	Yan et al., 2005
			Rescue of repetitive self-grooming behavior	Silverman et al., 2010
Lithium	Mood stabilizer	Mouse	Rescue of open field behavior	Yuskaitis et al., 2010
		Human	Corrected behavioral deficits in subjects with FXS	Berry-Kravis et al., 2008
Fenobam	mGluR5 inhibitor	Human	Correction of PPI	Berry-Kravis et al., 2009