Table 2c.
Antibody Responses to the Monovalent 2009 Influenza A (H1N1) Vaccine among Participants ≥35 Years Old
| Antibody Level | Total Cohort | HIV+ | HIV- | Unadjusted p-value1 | Adjusted OR2 (95% CI) | Adjusted p-value2 |
|---|---|---|---|---|---|---|
|
Baseline/Day 0 | ||||||
| GMT ≤1:10 | 43/65 (66%) | 23/32 (72%) | 20/33 (61%) | 0.434 | ||
| GMT >1:10 | 22/65 (34%) | 9/32 (28%) | 13/33 (39%) | |||
|
Participants with Baseline Titer ≤1:10 (Seroconversion) | ||||||
| Day 28: Titer ≥1:40 | 24/43 (56%) | 9/23 (39%) | 15/20 (75%) | 0.031 | 0.10 (0.01, 0.89) | 0.055 |
| Month 6: Titer ≥1:40 | 17/43 (40%) | 5/23 (22%) | 12/20 (60%) | 0.014 | 0.07 (0.01, 0.65) | 0.029 |
|
All Participants Regardless of Baseline Titer (Seroprotection) | ||||||
| Day 28: Titer ≥1:40 | 44/65 (68%) | 18/32 (56%) | 26/33 (79%) | 0.066 | 0.24 (0.05, 1.07) | 0.072 |
| Month 6: Titer ≥1:40 | 36/65 (55%) | 12/32 (38%) | 24/33 (73%) | 0.006 | 0.16 (0.03, 0.62) | 0.013 |
|
All Participants with a Day 28 Titer ≥1:40 | ||||||
| Month 6: Titer ≥1:40 | 35/44 (80%) | 12/18 (67%) | 23/26 (88%) | 0.128 | 0.36 (0.05, 2.25) | 0.287 |
1
Unadjusted p-value from Fisher’s exact test or T-test comparing HIV-infected with HIV-uninfected subjects.
2
Adjusted p-value from logistic regression comparing HIV-infected with HIV-uninfected subjects. Adjusted for age, race, number of seasonal influenza vaccinations in past three years, and number of household members.
CI, confidence interval; N, number; OR, odds ratio.