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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Pain. 2011 Feb 15;152(5):1052–1060. doi: 10.1016/j.pain.2011.01.018

Figure 3. Spinally administered MSVIII-19 selectively reduces thermal hypersensitivity in the formalin model.

Figure 3

Thermal or mechanical baselines were taken, followed by paw injection with 5% formalin. Three hours after formalin injection, mice were tested for thermal (A) or mechanical (B) sensitivity. The mice then received an intrathecal injection of either vehicle or MSVIII-19 (0.5 nmol), and were then tested for post-treatment thermal or mechanical sensitivity. Formalin induced significant thermal and mechanical hypersensitivity relative to pre-formalin baselines (P < 0.01; ANOVA with Tukey’s post-hoc test). Thermal hypersensitivity was significantly reduced by MSVIII-19 relative to vehicle, whereas mechanical hypersensitivity was not affected. *** p< 0.001