Figure 6.
Correlation of memory B cells in the immunized macaques from the study evaluating envelope boosting with functional antibody activities and chronic phase protection. HIV Env-specific IgG and IgA specific activities 4 weeks post-challenge are directly correlated with ADCC titer (A), ADCVI (B), and transcytosis inhibition (C) at the same time point. Post-challenge HIV Env-specific IgG and IgA specific activities are inversely correlated with chronic phase viremia over weeks 8 to 40 post-challenge (D).