Table 2.
Basic sleep log-, actigraph-, and polysomnography (PSG)-derived sleep characteristics for subjects with (0602+, n=11) or without (0602-, n=35) the DQB1*0602 allele. Sleep logs and actigraphy were averaged over two weeks (except only one week for “Rested”) of at-home collection, while PSG data were averaged over two nights (one subject from each group had only one usable night of PSG collected). Data were averaged within subjects then between subjects and are presented as mean ± SD. P-values were determined using unpaired t-Tests corrected for multiple comparisons (7 in sleep log data, 5 in actigraphy data, and 18 in PSG data). SE: sleep efficiency; WASO: wake after sleep onset; ISA: intrasleep awakening; NREM: non-rapid eye movement sleep; REM: rapid eye movement sleep; S1: stage 1, NREM; S2: stage 2, NREM; S3/4: combined stages 3 and 4, NREM; RDI: Respiratory Disturbance Index.
| 0602+ | 0602- | P-value | ||
|---|---|---|---|---|
| Sleep logs derived | Time in Bed | 517 ± 40.6 | 502 ± 63.2 | 0.49 |
| Total Sleep Time | 351 ± 52.3 | 341 ± 51.8 | 0.56 | |
| SE | 68.3 ± 8.98 | 68.7 ± 11.5 | 0.92 | |
| WASO | 73.2 ± 25.4 | 66.1 ± 45.0 | 0.62 | |
| Sleep Latency | 31.7 ± 26.9 | 33.0 ± 28.2 | 0.89 | |
| “Rested” | 3.16 ± 0.858 | 3.96 ± 1.02 | 0.02* | |
| Actigraph-derived | Time in Bed | 521 ± 37.1 | 499 ± 60.2 | 0.25 |
| Total Sleep Time | 436 ± 57.0 | 395 ± 54.8 | 0.04 | |
| SE | 83.6 ± 7.35 | 79.4 ± 7.33 | 0.11 | |
| WASO | 54.2 ± 22.5 | 63.7 ± 32.4 | 0.37 | |
| Sleep Latency | 14.2 ± 15.4 | 21.9 ± 14.8 | 0.14 | |
| Polysomnography-derived | Total Sleep Time | 340 ± 70.3 | 353 ± 51.5 | 0.51 |
| Sleep Latency | 18.9 ± 13.9 | 17.4 ± 20.9 | 0.83 | |
| SE | 77.7 ± 15.1 | 82.6 ± 8.06 | 0.33 | |
| WASO | 98.0 ± 63.7 | 74.9 ± 35.6 | 0.27 | |
| ISA > 2 min | 7.00 ± 3.77 | 6.04 ± 2.43 | 0.32 | |
| All transitions | 186 ± 54.4 | 186 ± 45.9 | 0.99 | |
| Transitions, NREM to REM | 20.5 ± 7.75 | 20.1 ± 7.10 | 0.89 | |
| Transitions, REM to NREM | 16.1 ± 6.30 | 15.8 ± 6.29 | 0.88 | |
| REM (min) | 61.2 ± 18.0 | 58.8 ± 17.8 | 0.69 | |
| REM (%) | 17.3 ± 4.08 | 16.3 ± 3.93 | 0.51 | |
| REM latency (min) | 69.1 ± 25.1 | 84.1 ± 37.9 | 0.23 | |
| S1 (min) | 156 ± 55.2 | 178 ± 46.3 | 0.19 | |
| S1 (%) | 45.7 ± 11.9 | 50.6 ± 9.72 | 0.17 | |
| S2 (min) | 112 ± 36.6 | 110 ± 34.2 | 0.85 | |
| S2 (%) | 34.3 ± 12.0 | 31.6 ± 9.51 | 0.44 | |
| S3/4 (min) | 10.0 ± 14.9 | 5.49 ± 8.67 | 0.36 | |
| S3/4 (%) | 2.77 ± 3.96 | 1.50 ± 2.24 | 0.33 | |
| O2 saturation (%) | 87.8 ± 7.82 | 88.5 ± 6.21 | 0.75 | |
| RDI | 3.79 ± 2.30 | 3.14 ± 2.69 | 0.48 |