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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Pain. 2011 Mar 9;152(5):1182–1191. doi: 10.1016/j.pain.2011.01.046

Figure 1.

Figure 1

A: Colonic afferents are unresponsive to modulation by estradiol. A: There was no difference in the stimulus response functions of colonic afferents to graded intensities of CRD between intact and OVx rats, n=18–38/group. B: Photomicrographs of the same field from an L6 DRG showing colonic afferents retrogradely labeled with ctb-594 (Bi); the same field labeled for ERα (Bii); and the merged image showing a lack of double labeled cells (Biii). Arrowheads point to examples of colonic afferents that do not express ERα. C: Photomicrographs of the same field from an L6 DRG showing bladder afferents retrogradely labeled with ctb-594 (Ci); the same field labeled for ERα (Cii); and the merged image showing several double labeled cells (Ciii). Arrowheads point to bladder afferents that express ERα.