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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Pain. 2011 Mar 9;152(5):1182–1191. doi: 10.1016/j.pain.2011.01.046

Figure 2.

Figure 2

Spinal E2 increases visceral nociceptive processing in OVx rats. A: I.t. E2 facilitated the visceromotor response (vmr) for all doses 48 hours post injection (*, **, *** p<0.05, 0.01, 0.005 vs. saline at 48 hours; n=8–14/group). At the earlier time point there was a tendency for E2 to increase the vmr (pooled drug vs. saline, p<0.05). B: a single i.t. injection of ICI 182,780 in intact female rats had no effect on the vmr. Four daily injections of ICI attenuated the vmr. * p<0.05 vs. pre-injection.