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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Pain. 2011 Mar 9;152(5):1182–1191. doi: 10.1016/j.pain.2011.01.046

Figure 3.

Figure 3

E2 increases the phosphorylation of the Extracellular-Signal-Regulated Kinase (pERK) induced by colorectal distention in OVx rats. A, B: Representative sections of CRD-induced pERK expression in the LS spinal dorsal horn from a vehicle- (A) and E2-treated (B) rat. C: Western blots (C) and quantified data (D) showing that CRD significantly increased the pERK2 level in E2-treated rats. Values represent the pERK1/2 to ERK1/2 ratio normalized to vehicle + CRD rats. * p<0.05 vs. vehicle + CRD.