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64Cu labeled RGD nanocluster modified DNA/PEI polyplexes (DNA/PEI-Au). DOTA conjugated PEI is formed by reaction with NHS-DOTA (1). Radiolabeling of PEI is achieved by chelating 64Cu chloride to DOTA conjugated PEI (2). 64Cu labeled PEI is mixed with plasmid DNA allowing for polyplex formation (3). RGD nanoclusters are conjugated to the 64Cu labeled DNA/PEI polyplexes via UV activated crosslinker [6](4).
