Figure 7. Effect of JNK or P38 inhibitors on thrombin-induced apoptosis.
Thrombin-induced apoptosis is attenuated by JNK or P38 inhibitors. Cultured DMV neurons were treated with inhibitors specific for JNK(SP600125 10−5M), P38 (SB203580 10−5M) or both before exposure to thrombin (10 U ml−1). Apoptosis was evaluated by Tunel (left panel) and ELISA(right panel). Results are expressed as mean±SEM. * p<0.05.