Table 2.
Non-NASH |
NASH |
||||||
---|---|---|---|---|---|---|---|
Variable | Fibrosis Stage 0–2 N=200 |
Fibrosis Stage 3–4 N=24 |
Total N=224 |
Fibrosis Stage 0–2 N=216 |
Fibrosis Stage 3–4 N=101 |
Total N=317 |
p- value§ |
Age (yrs) | 46 ± 12 | 55 ± 7 | 47 ± 12 | 46 ± 12 | 53 ± 11 | 48 ± 12 | <0.001 |
Males | 94 (47) | 10 (42) | 104 (46) | 86 (40) | 26 (26) | 112 (35) | 0.005 |
Caucasian | 142 (71) | 20 (83) | 162 (72) | 160 (74) | 80 (79) | 240 (76) | 0.112 |
BMI (kg/m2) | 34 ± 6.4 | 36 ± 7.6 | 34 ± 6.6 | 34 ± 6.4 | 35 ± 5.6 | 34 ± 6.1 | 0.683 |
Hypertension | 78 (39) | 10 (42) | 88 (39) | 92 (43) | 59 (58) | 151 (48) | 0.013 |
Type 2 diabetes | 29 (15) | 7 (29) | 36 (16) | 40 (19) | 29 (29) | 69 (22) | 0.017 |
Hemoglobin (g/dl) | 15 ± 1.3 | 14 ± 1.3 | 15 ± 1.3 | 15 ± 1.5 | 14 ± 1.5 | 14 ± 1.5 | 0.017 |
WBC (×109/l) | 7.0 ± 1.9 | 5.8 ± 1.9 | 6.8 ± 2.0 | 7.1 ± 2.1 | 6.8 ± 2.1 | 7.0 ± 2.1 | 0.970 |
Platelet (×109/l) | 253 ± 67 | 166 ± 59 | 244 ± 71 | 253 ± 62 | 208 ± 72 | 239 ± 69 | <0.001 |
AST (IU/l) | 35 | 46 | 36 | 50 | 56 | 53 | <0.001 |
(27–49) | (35–57) | (28–50) | (36–73) | (42–79) | (37–74) | ||
ALT (IU/l) | 57 | 47 | 57 | 74 | 62 | 68 | <0.001 |
(36–86) | (34–75) | (35–83) | (49–111) | (45–96) | (47–103) | ||
Alkaline | 76 | 100 | 78 | 79 | 91 | 82 | <0.001 |
Phosphatase (IU/l) | (62–95) | (71–115) | (63–100) | (65–96) | (70–118) | (67–103) | |
Bilirubin (mg/dl) | 0.7 | 0.8 | 0.7 | 0.6 | 0.7 | 0.6 | 0.076 |
(0.5–0.9) | (0.6–1.2) | (0.5–1.0) | (0.5–0.9) | (0.5–0.9) | (0.5–0.9) | ||
Albumin (g/dl) | 4.2 ± 0.4 | 4.0 ± 0.4 | 4.2 ± 0.4 | 4.2 ± 0.4 | 4.1 ± 0.4 | 4.2 ± 0.4 | 0.724 |
INR | 1.00 ± 0.18 | 1.09 ± 0.12 | 1.01 ± 0.17 | 1.01 ± 0.12 | 1.05 ± 0.12 | 1.02 ± 0.12 | 0.019 |
Fasting glucose | 95 | 96 | 96 | 96 | 100 | 97 | 0.341 |
(mg/dl) | (87–109) | (87–112) | (87–110) | (86–108) | (87–118) | (86–111) | |
Fasting insulin | 16 | 25 | 17 | 17 | 24 | 20 | <0.001 |
(µU/ml) | (11–23) | (17–37) | (11–24) | (12–26) | (16–40) | (13–30) | |
Triglycerides | 140 | 110 | 137 | 158 | 143 | 153 | 0.008 |
(mg/dl) | (100–203) | (92–163) | (100–200) | (112–238) | (105–179) | (109–218) | |
LDL-cholesterol | 123 ± 34 | 97 ± 30 | 120 ± 34 | 123 ± 34 | 111 ± 33 | 119 ± 34 | 0.056 |
(mg/dl) | |||||||
HDL-cholesterol | 44 ± 11 | 48 ± 14 | 44 ± 12 | 43 ± 12 | 43 ± 12 | 43 ± 12 | 0.715 |
(mg/dl) | |||||||
Biopsy length | 18 ± 8.7 | 17 ± 8.1 | 18 ± 8.7 | 20 ± 9.3 | 21 ± 9.9 | 20 ± 9.5 | 0.001 |
(mm) | |||||||
Steatohepatitis | 0 (0) | 0 (0) | 0 (0) | 216 (100) | 101 (100) | 317 (100) | n/a |
Values are means ± SD, medians (IQR), or counts (%), as appropriate
P values from univariate ordinal logistic regression, Mann-Whitney, or chi-square test, as appropriate
Non-Hispanic white