Figure 5.

Estrous cycle pattern in control and Jak2 G^−/− mice. Vaginal cytology was assessed for 15 d in control and Jak2 G^−/− mice. A, Plotted are the percentage of females that exhibited one complete cycle during the 15 d (left two bars) or two complete cycles during the 15 d (right two bars). Numbers of mice used to calculate the percentage are at the top of the bars. B, Time in each estrous cycle phase. E, Estrus; P, proestrus; M/D, metestrus/diestrus. C, Representative estrous cycles of control, Jak2 G^−/− with irregular cycles, and Jak2 G^−/− without cycles. D, OVX mice were implanted with an estradiol pump on day 0 and bled on day 2 (control n = 4 vs Jak2 G^−/− n = 7). Values are mean ± SEM, and significance is indicated.