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Tlr2-dependent DNA methylation changes at Anpep correlate with its expression. A) Methylation of the Anpep-associated SmaI/XmaI interval (calculated from both flanking sites; see Materials and Methods) increased in Tlr2−/− colonic mucosa (WT, n=8; Tlr2−/−, n=9; P<0.0001). B) Anpep expression decreased in Tlr2−/− colonic mucosa (WT, n=10; Tlr2−/−, n=11; P=0.017). C) Methylation at Anpep inversely correlated with expression (r=−0.8; n=13; P=0.008).
