Table 5.
Increased inflammatory cytokines induced by CKD are suppressed by treatment with the anti-myostatin peptibody
| Cytokine | Treatment |
P value |
|||
|---|---|---|---|---|---|
| Sham | CKD-PBS | CKD-peptibody | CKD vs. sham | CKD-peptibody vs. CDK-PBS | |
| CD40 (pg/ml) | 101.5 ± 33.70 | 204.5 ± 74.30 | 181 ± 9.59 | 0.045* | 0.554 |
| Fibrinogen (μg/ml) | 156.75 ± 34.87 | 2877.5 ± 1007.68 | 323.25 ± 306.50 | 0.0016* | 0.003* |
| KC (ng/ml) | 0.065 ± 0.03 | 0.086 ± 0.04 | 0.081 ± 0.03 | 0.407 | 0.849 |
| IFN-γ (pg/ml) | 16.15 ± 5.04 | 17.55 ± 2.58 | 12.57 ± 2.66 | 0.638 | 0.036* |
| IL-7 (ng/ml) | 0.26 ± 0.10 | 0.37 ± 0.17 | 0.26 ± 0.10 | 0.322 | 0.314 |
| M-CSF-1 (ng/ml) | 7.31 ± 2.51 | 11.61 ± 2.08 | 7.48 ± 1.0 | 0.039* | 0.012* |
| MIP-1β (pg/ml) | 224 ± 58.76 | 255.5 ± 41.4 | 240.75 ± 73.56 | 0.414 | 0.739 |
| MPO (ng/ml) | 135.9 ± 53.89 | 208.5 ± 135.66 | 168.5 ± 38.79 | 0.358 | 0.591 |
| TNF-α (ng/ml) | 0.1 ± 0.06 | 0.151 ± 0.03 | 0.075 ± 0.04 | 0.189 | 0.033* |
| IL-6 (pg/ml) | 5.8 ± 0.48 | 10.48 ± 2.23 | 3.05 ± 0.73 | 0.041* | 0.036* |
Values are means ± se. M-CSF-1, macrophage colony-stimulating factor-1; MIP-1β, macrophage inflammatory protein-1β; MPO, myeloperoxidase.
*
P < 0.05.