Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Corresponding Enzymes in Prokaryotic and Eukaryotic NHEJ Components
| Functional component | Prokaryotes | Eukaryotes | |
|---|---|---|---|
| S. cerevisiae | Multicellular eukaryotes | ||
| Toolbelt protein | Ku (30-40kDa) | Ku 70/80 | Ku 70/80 |
| Polymerase | POL domain of LigD | Pol4 | Polmu and lambda |
| Nuclease | ? | Rad50:Mre11:Xrs2 (FEN-1) | Artemis:DNA-PKcs |
| Kinase/Phosphatase | PE domain of LigD | Tpp1 and others | PNK and others |
| Ligase | LIG domain of LigD | Nej1:Lif1:Dnl4 | XLF:XRCC4:DNA ligase IV |
