Table 3. Effects of DTG on Saccharin and Sucrose Self-Administration.
| Vehicle | DTG | |
|---|---|---|
| Saccharin (number of lever presses) | ||
| Baseline | 43.5±8.7 | 45.8±10.0 |
| Day 1 | 51.6±11.0 | 72.0±13.2 |
| Day 2 | 62.2±9.1 | 114.5±19.1* |
| Day 3 | 55.6±10.5 | 159.8±18.6** |
| Day 4 | 55.8±9.4 | 145.3±5.9*** |
| Day 5 | 61.8±8.9 | 154.5±12.0*** |
| Day 6 | 49.4±9.7 | 118.7±22.0* |
| Day 7 | 41.6±10.6 | 130.5±16.5** |
| Sucrose (number of lever presses) | ||
| Baseline | 54.6±12.8 | 57.0±8.4 |
| Day 1 | 60.6±12.7 | 72.0 ±9.4 |
| Day 2 | 61.2±13.7 | 92.2±15.4 |
| Day 3 | 62.0±14.5 | 114.0±19.6 |
| Day 4 | 65.4±13.4 | 180.2±7.8*** |
| Day 5 | 84.0±9.2 | 176.2±16.2** |
| Day 6 | 75.2±10.9 | 122.3±32.2 |
| Day 7 | 76.4±13.4 | 166.5±9.8*** |
Effect of repeated subcutaneous pretreatment (twice a day for 7 days) with the σ receptor agonist DTG on saccharin (0.04% w/v, left) or sucrose (1.5% w/v, right) self-administration on a fixed-ratio 1 schedule of reinforcement in sP rats during 60-min sessions (n=5–6/group). Data represent mean±SEM intake of the number of lever presses. *p<0.05, **p<0.01, ***p<0.001 vs vehicle-treated group (Student's t test).