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. Author manuscript; available in PMC: 2011 Apr 19.
Published in final edited form as: J Neuropathol Exp Neurol. 2009 Dec;68(12):1282–1293. doi: 10.1097/NEN.0b013e3181c1da10

Figure 4.

Figure 4

Co-immunostaining of active Casp6 with PHF-1. Micrographs show colocalization of active Casp6 (brown) and PHF-1 (red) in (A) neurofibrillary tangles (black arrow), (B) neuropil threads (black arrowhead) and a structure resembling a tangle stained only with anti-active Casp6 (white arrow). Left panel is a lower magnification indicating the area where the picture was taken (black arrow). Scale bar = 1 mm. Right panel is a higher magnification. Scale bar = 50 µm. (C) Micrograph showing punctate cytoplasmic anti-active Casp6 immunoreactivity in the APP Arctic case. The right panel represents a magnified image of the anti-active Casp6 immunopositive neurons with more or less PHF-1 immunoreactivity.