Table 4.
Paired Helical Filament-1 Immunohistochemistry
| Case | Mutation | Region | NP | NFT | NPT |
|---|---|---|---|---|---|
| 8–02 | Arctic APP E693G | S/MTG | 2–3 | 2–3 | 2–3 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3 | ||
| 2003–002 | PSEN I A431E | S/MTG | 3 | 3 | 4 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 4 | ||
| 2006–093 | PSEN I A431E | S/MTG | 3 | 3 | 3 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3 | ||
| 2001–090 | PSEN I F105L | S/MTG | 3 | 3 | 3 |
| Hippocampus | 1 | 3 | 1 | ||
| ERC | 3 | 3 | 3 | ||
| 2008–073 | PSEN I F105L | S/MTG | 3 | 3 | 4 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 4 | ||
| 2000–007 | PSEN I V261F | S/MTG | 3 | 3 | 3 |
| Hippocampus | 0 | 3 | 3 | ||
| ERC | 3 | 3 | 3 | ||
| 2002–086 | PSEN I V261F | S/MTG | 3 | 3 | 3–4 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3–4 | ||
| 2003–041 | PSEN I Y115C | S/MTG | 3 | 3 | 3–4 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3–4 | ||
| 2007–093 | PSEN I Y115C | S/MTG | 3 | 3 | 3–4 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3 | ||
| 2002–066 | PSEN II N141I | S/MTG | 3 | 3 | 3 |
| Hippocampus | 3 | 3 | 3 | ||
| ERC | 3 | 3 | 3 |
Numerical scores indicate relative abundance of staining.
APP = amyloid precursor protein; PSEN = presenilin; NFT = neurofibrillary tangles; NP = neuritic plaques; NPT – neuropil threads; ERC = entorhinal cortex; S/MTG = superior/medial temporal gyrus.