Fig. 1. Yeast two-hybrid analysis of ArsD mutants exhibiting increased interaction with ArsA.
S. cerevisiae strain AH109 bearing pBD-k-D wild typeArsD or mutants (indicated at left) and either pAD-A (A) or pAD-D (B) plasmids was grown in SD medium overnight and inoculated with 10-fold serial dilutions on SD agar plates lacking histidine and supplemented with the indicated concentrations of 3-AT. The plates were incubated at 30 °C for 3 days and scored for growth.