Table 3.

HRs for Individual Events per Change in FGF23, ucMGP, or Fetuin-A Level^*

Variable	Per Doubling of FGF23†		Per 1000-nM Greater ucMGP Level		Per 0.1-g/L Greater Fetuin-A Level
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Death (n =220)	1.54 (1.39–1.70)	<0.001	0.78 (0.68–0.90)	0.001	0.92 (0.81–1.05)	0.22
Cardiovascular event (n =182)	1.49 (1.35–1.66)	0.004	0.84 (0.72–0.98)	0.029	1.08 (0.94–1.24)	0.28
Heart failure (n =119)	1.31 (1.08–1.59)	0.005	0.88 (0.72–1.08)	0.22	1.04 (0.87–1.25)	0.67
Myocardial infarction (n =88)	1.05 (0.85–1.30)	0.67	0.75 (0.59–0.95)	0.015	1.04 (0.85–1.26)	0.71
Stroke or transient ischemic attack (n =36)	1.50 (1.11–2.04)	0.008	1.00 (0.72–1.40)	0.99	1.09 (0.82–1.45)	0.55

FGF23 = fibroblast growth factor 23; HR = hazard ratio; ucMGP = uncarboxylated matrix Gla protein.

^*Adjusted for age; sex; race; waist-to-hip ratio; smoking status; hypertension; diabetes; systolic and diastolic blood pressures; estimated glomerular filtration rate; total and high-density lipoprotein cholesterol levels; C-reactive protein level; ejection fraction; peak exercise capacity; and use of aspirin, β-blockers, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, statins, or anticoagulants.

^†HRs for FGF23 as a continuous predictor are expressed as “per doubling of FGF23” because it was natural log–transformed for analysis.