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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nat Immunol. 2011 Feb 6;12(4):327–334. doi: 10.1038/ni.1996

Figure 7. Blimp-1 deficiency in T cells results in diminished IL-10 production and enhanced pulmonary inflammation.

Figure 7

CD4-Cre Prdm1fl/+ or CD4-Cre Prdm1fl/fl mice were infected with influenza. (a, b) At d7 p.i., the production of IL-10 and IFN-γ by CTL was measured by ICS. (b) The normalized percentages of IL-10+ or TNF+ cells in influenza-specific CTL (IFN-γ+) in CD4-Cre Prdm1fl/+ or CD4-Cre Prdm1fl/fl mice are depicted. (c) At d7 p.i., the levels of IL-10 and IFN-γ in BALF were determined through ELISA. (d) At d9 p.i., the numbers of lung monocytes and neutrophils were measured through flow cytometry. Numbers are the percentages of cells in gated population. *, P <= 0.05; **, P <= 0.01. (b, c) Data are from three pooled experiments. (e) WT or CD4-Cre Prdm1fl/fl T cells were transferred into Thy1.1+ WT mice and infected with influenza. At d7 p.i., the production of IL-10 and IFN-γ by CTL was measured by ICS following restimulation with influenza-infected BMDC. The normalized percentages of IL-10+ cells in influenza-specific CTL (IFN-γ+) from infected lungs are depicted. Pooled data from two experiments are represented.