Table 2.
LOH events on additional chromosomesa in Aprt mutants isolated from mouse kidneys.
| Aprt mutationb | clones w/LOHc | total LOH eventsd |
|---|---|---|
| Non-mutant (NM) | 0/23 (0%) | 0/252 (0%) |
| Chromosome loss (CL) | 15/39 (38%) | 28/428 (6.5%) |
| Mitotic recombination (MR) | 3/23 (13%) | 4/253 (1.6%) |
| Intragenic event (IE) | 2/25 (8%) | 4/275 (1.5%) |
| Statistical comparison (p values)e | ||
| NM vs. CL | <0.001 | <0.001 |
| MR vs. CL | 0.032 | 0.003 |
| IE vs. CL | 0.006 | 0.001 |
| NM vs. MR | 0.155 | 0.109 |
| NM vs. IE | 0.358 | 0.121 |
| MR vs. IE | 0.721 | 1.000 |
a
One polymorphic locus for each of 11 additional chromosomes (2, 3, 5, 6, 7, 9, 11, 12, 13, 14, and 15) was examined for LOH.
b
The mutational event on chromosome 8 that led to loss of Aprt expression in mutant clones; non-mutant clones were isolated, without selection, from mouse kidneys.
c
The number of clones with one of more LOH events divided by the number of clones examined.
d
The number of loci exhibiting LOH divided by the number of loci examined. Data from chromosome 8 are excluded.
e
Statistical comparisons using exact unconditional test. Significant differences are bolded.