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. 2011 Feb 16;36(6):1260–1274. doi: 10.1038/npp.2011.12

Figure 1.

Figure 1

The mGluR2/3 agonist LY379268 recovered the disrupted expression of NMDA receptors induced by subchronic MK-801 administration. The drugs were administered once a day for 5 days (i.p.). LY379268 was applied 50 min after MK-801 injection and brain tissues were collected for western blotting 50 min after the last injection. (a) Subchronic administration of MK-801 at 0.033 mg/kg significantly increased the total proteins of NR2A and NR2B subunits and decreased NR2B phosphorylation at Ser1303 and Tyr1472 (P<0.05). LY379268 treatment (0.3 mg/kg) completely recovered the disrupted expression of NMDA receptors induced by MK-801. Both total protein and NR2B phosphorylation were recovered to control levels (P>0.05). (b) In contrast, MK-801 at 1.0 mg/kg dramatically and significantly decreased the total proteins of NR2A and NR2B subunits, as well as phosphorylation of Ser1303 and Tyr1472 (P<0.05). LY379268 treatment (3 mg/kg), however, only partially but significantly restored the total protein levels of NR2A and NR2B subunits (P<0.05), although the phosphorylation was completely recovered to control levels. *increase, P<0.05; #decrease, P<0.05.