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. Author manuscript; available in PMC: 2011 Apr 19.
Published in final edited form as: Proc Natl Cancer Conf. 1972;7:425–436.

TABLE 4.

Development of Cancers in 30 Patients with Nonmalignant Diseases Treated with Immunosuppressive Agents

Disease No. of Cases Treated Major Agent Used* Type of Cancer
Chronic cold hemagglutinin disease 1 Chlorambucil Reticulum cell sarcoma (1)
Rheumatoid arthritis 4 Cyclophosphamide Lymphoma (2); leukemia (2)
Nephrotic syndrome 2 Azathioprine Lymphoma (1); bronchial carcinoma (1)
S.L.E. 2 Azathioprine Lymphoma (1); malignant melanoma (1)
Ulcerative colitis 1 Azathioprine Carcinoma of colon (1)
Psoriasis 20 Methotrexate (19); Aminopterin (1) Various visceral cancers (17); skin cancers (3)
*

In some cases more than one agent was used.