TABLE 5.
New Malignancies in 61 Patients with Cancer Treated with Chemotherapy
| Initial Cancer | Number of Cases | Major Agent Used* | Number of Cases | Second Cancer | Number of Cases |
|---|---|---|---|---|---|
| Multiple myeloma | 21 | Melphalan; | 19 | Acute leukemia; | 21† |
| Cyclophosphamide | 2 | Basal cell carcinoma of skin | 1† | ||
| Chronic granulocytic leukemia | 13 | Busulfan; | 10 | Reticulum cell sarcoma | 4 |
| Multiple; | 2 | ||||
| Urethane | 1 | Lymphosarcoma | 3 | ||
| Hodgkin’s disease | 2 | ||||
| Carcinoma of vulva | 1 | ||||
| Carcinoma of breast | 1 | ||||
| Carcinoma of pancreas | 1 | ||||
| Carcinoma of lung | 1 | ||||
| Chronic lymphocytic leukemia | 3 | Chlorambucil | 3 | Myelomonocytic leukemia | 1 |
| Acute myeloblastic leukemia | 1 | ||||
| Acute leukemia | 1 | ||||
| Polycythemia rubra vera | 9 | Melphalan; | 7 | Acute leukemia | 6 |
| Triethylene melamine | 1 | Glioblastoma multiforme | 1 | ||
| Busulfan | 1 | Carcinoma of prostate | 1 | ||
| Carcinoma of colon | 1 | ||||
| Lymphosarcoma | 4 | Cyclophosphamide | 4 | Carcinoma of skin | 2 |
| Carcinoma of stomach | 1 | ||||
| Carcinoma of bladder | 1 | ||||
| Hodgkin’s disease | 3 | Multiple; | 2 | Carcinoma of bladder | 2 |
| Cyclophosphamide | 1 | Carcinoma of lung | 1 | ||
| Choriocarcinoma | 3 | Methotrexate | 3 | Carcinoma of cervix in situ | 2 |
| Hodgkin’s disease | 1 | ||||
| Carcinoma of ovary | 3 | Thiotepa; | 2 | Acute leukemia | 3 |
| Methotrexate | 1 | ||||
| Adenocarcinoma of lung | 1 | Thiotepa | 1 | Acute leukemia | 1 |
| Primary myelofibromatosis | 1 | Cyclophosphamide | 1 | Reticulum cell sarcoma | 1 |
*
In some cases more than one agent was used.
†
One patient developed acute leukemia and a basal cell carcinoma of the skin.