Table 8.

Regression analysis of liver enzymes and measures of metabolic syndrome and insulin resistance on livery histology (NAS≥5 and NASH diagnosis)

	ALT (U/L)
Models	β	95% CI	P
One variable model
NAS≥5	30.9	23.0 – 38.8	<0.0001
NASH diagnosis	25.5	17.3 – 33.7	<0.0001
Two variable models
NAS≥5	24.5	15.1 – 34.0	<0.0001
NASH Dx	11.8	2.1 – 21.3	0.02
	AST (U/L)
Models	β	95% CI	P
One variable model
NAS≥5	25.9	20.2 – 31.7	<0.0001
NASH diagnosis	25.7	19.8 – 31.6	<0.0001
Two variable models
NAS≥5	17.3	10.4 – 24.1	<0.0001
NASH Dx	16.1	9.1 – 23.0	<0.0001
	Diabetes
Models	OR	95% CI	P
One variable model
NAS≥5	1.33	0.99 – 1.79	0.06
NASH diagnosis	1.92	1.41 – 2.62	<0.0001
Two variable models
NAS≥5	0.90	0.63 – 1.29	0.58
NASH Dx	2.04	1.40 – 2.96	<0.0001
	Metabolic Syndrome
Models	OR	95% CI	P
One variable model
NAS≥5	1.21	0.93 – 1.58	0.16
NASH diagnosis	1.43	1.09 – 1.98	0.009
Two variable models
NAS≥5	0.98	0.71 – 1.36	0.91
NASH Dx	1.45	1.04 – 2.01	0.03
	HOMA-IR
Models	β	95% CI	P
One variable model
NAS≥5	1.39	0.48 – 2.31	0.003
NASH diagnosis	1.70	0.77 – 2.62	<0.0001
Two variable models
NAS≥5	0.68	−0.41 – 1.77	0.22
NASH Dx	1.32	0.21 – 2.42	<0.0001
	QUICKI (X 1,000 )
Models	β	95% CI	P
One variable model
NAS≥5	−7.17	−12.49 – −1.85	0.008
NASH diagnosis	−9.24	−14.63 – −3.86	0.001
Two variable models
NAS≥5	−3.12	−9.45 – −3.86	0.33
NASH Dx	−7.51	−13.95 – −1.06	0.02