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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Arthritis Rheum. 2011 Apr;63(4):1086–1096. doi: 10.1002/art.30230

Figure 2.

Figure 2

Not all autoreactive IgM protected against lupus nephritis. A&B. Decreased levels of urine protein and of immune complex deposition in mice receiving the AID-deficient derived anti-dsDNA IgM (AID−/−) compared to mice receiving an anti-phospholid IgM (AP), anti-Smith antigen IgM (AS), a non-autoreactive IgM (NA) and PBS. C&D. Mononuclear cell infiltration in the kidneys and glomerulonephritis was also reduced in mice receiving the AID-deficient derived anti-dsDNA IgM. Glomerulonephritis scores for each group were based from analysis of 20 randomly selected glomeruli from each group visualized with hematoxylin and eosin stain (H&E) and Periodic Acid Schiff stain (PAS). Only the anti-dsDNA IgM from AID−/− background was significant (other comparisons had p values > 0.10). Mann-Whitney Rank Sum Test was used to test for significance. Error bars depict standard error.