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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Arthritis Rheum. 2011 Apr;63(4):1086–1096. doi: 10.1002/art.30230

Figure 4.

Figure 4

Mice receiving anti-dsDNA IgM displayed evidence of decreased inflammation and of ongoing apoptosis in the kidneys. A. Staining of kidneys with anti-F4/80 antibody which recognizes a glycoprotein expressed by macrophages, is reduced in MRL/lpr mice receiving anti-dsDNA IgM compared to MRL/lpr mice receiving PBS control. B. Staining of kidneys with anti-cleaved-caspase-3 antibody, which binds to the large fragment of activated caspase-3 following cleavage during apoptosis is also reduced in MRL/lpr mice receiving anti-dsDNA IgM. Positive cells are stained brown. A normal C57BL6 control is included. Significant P values were obtained with the Mann-Whitney Rank Sum Test. Error bars depict standard error.