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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Hepatology. 2011 Apr;53(4):1373–1382. doi: 10.1002/hep.24190

Fig. 3.

Fig. 3

Poly I:C or IFN-γ treatments inhibits liver fibrosis induced by 2-week CCl4 but not by 10-week CCl4 treatment. Two-week or 10-week CCl4-treated mice were co-injected with poly I:C for the last 2 weeks. (A-B) Liver tissues were collected for immunohistochemistry analyses with anti-α-SMA antibody (A), measurement of hepatic hydroxyproline content (B). (C) HSCs were isolated from the mouse liver and then subject to Western blotting. (D-E) Mice were injected with CCl4 plus IFN-γ for 2 weeks, or with CCl4 for 8 weeks and then co-treatment of CCl4 plus IFN-γ for an additional 2 or 4 weeks. Liver tissues were subsequently collected and subject to immunohistochemistry analyses with anti-α-SMA antibody (D) and measurement of hepatic hydroxyproline content (E). (F) Protein extracts from HSCs were subject to Western blotting. *P<0.05.