Table 1.
X chromosome genes whose expression are signficantly correlated with either carboplatin or cisplatin sensitivity via a meta-analysis in the CEU and the CEU and YRI samples.
| gene name | transcript cluster ID | Affymetrix |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| combined CEU and YRI | CEU | YRI | |||||||
| meta p values | meat q values | p values | q values | ||||||
| carboplatin | cisplatin | carboplatin | cisplatin | carboplatin | cisplatin | carboplatin | cisplatin | ||
| CD99L2 * | 4025771 | 1.70E-08 | 4.20E-09 | 2.73E-06 | 9.02E-07 | 6.23E-04 | 2.37E-06 | 1.24E-06 | 7.55E-05 |
| GPR174 * | 3982612 | 4.05E-07 | 7.01E-06 | 3.25E-05 | 7.54E-04 | 1.78E-05 | 1.15E-03 | 1.22E-03 | 3.91E-04 |
| STS * | 3967689 | 6.29E-06 | 2.85E-05 | 2.69E-04 | 1.53E-03 | 8.89E-06 | 8.16E-05 | 4.50E-02 | 2.48E-02 |
| DLG3 * | 3980643 | 6.70E-06 | 5.50E-04 | 2.69E-04 | 1.31E-02 | 1.11E-03 | 7.34E-02 | 3.85E-04 | 6.88E-04 |
| MID1IP1 * | 3974098 | 2.24E-05 | 1.12E-05 | 7.19E-04 | 8.00E-04 | 1.35E-01 | 1.36E-02 | 1.16E-05 | 5.42E-05 |
| CLIC2 | 4027769 | 3.40E-05 | 4.24E-03 | 9.11E-04 | 5.06E-02 | 2.60E-05 | 2.07E-03 | 9.39E-02 | 2.38E-01 |
| GRPR | 3970024 | 1.00E-04 | 8.04E-03 | 2.30E-03 | 6.66E-02 | 1.03E-02 | 1.26E-02 | 7.67E-04 | 8.10E-02 |
| TMEM164 * | 3987029 | 1.19E-04 | 1.75E-03 | 2.39E-03 | 2.35E-02 | 1.06E-03 | 2.29E-03 | 8.92E-03 | 7.96E-02 |
| ACSL4 * | 4017810 | 3.89E-04 | 2.64E-04 | 6.94E-03 | 7.43E-03 | 4.27E-04 | 6.12E-04 | 8.08E-02 | 3.69E-02 |
| MAP3K15 * | 4001850 | 5.44E-04 | 1.39E-04 | 7.35E-03 | 5.99E-03 | 1.97E-01 | 2.74E-02 | 2.53E-04 | 4.10E-04 |
| FAM3A * | 4027387 | 5.37E-04 | 9.10E-04 | 7.35E-03 | 1.78E-02 | 1.58E-01 | 6.52E-02 | 3.11E-04 | 1.35E-03 |
| WWC3 | 3968397 | 5.49E-04 | 3.28E-02 | 7.35E-03 | 1.43E-01 | 5.21E-04 | 8.38E-02 | 9.67E-02 | 6.26E-02 |
| CLCN5 * | 3977299 | 9.02E-04 | 8.41E-04 | 1.04E-02 | 1.78E-02 | 1.57E-02 | 6.82E-03 | 5.54E-03 | 1.18E-02 |
| CDKL5 | 3970642 | 8.49E-04 | 6.05E-02 | 1.04E-02 | 1.86E-01 | 2.55E-02 | 3.04E-01 | 3.19E-03 | 3.61E-02 |
| PJA1 | 4011464 | 1.18E-03 | 6.54E-03 | 1.26E-02 | 6.52E-02 | 2.60E-04 | 2.87E-02 | 4.50E-01 | 2.81E-02 |
| CTPS2 * | 4000839 | 1.73E-03 | 1.71E-04 | 1.40E-02 | 6.13E-03 | 9.71E-02 | 4.78E-02 | 1.86E-03 | 2.94E-04 |
| ATP6AP2 * | 3974556 | 1.46E-03 | 1.07E-03 | 1.40E-02 | 1.83E-02 | 2.18E-02 | 8.03E-03 | 6.83E-03 | 1.32E-02 |
| CNKSR2 | 3971219 | 1.72E-03 | 1.95E-02 | 1.40E-02 | 1.22E-01 | 5.34E-02 | 3.36E-01 | 3.34E-03 | 8.46E-03 |
| MED12 | 3980758 | 1.65E-03 | 3.64E-02 | 1.40E-02 | 1.51E-01 | 2.44E-04 | 1.18E-02 | 6.97E-01 | 5.04E-01 |
| GDI1 | 3996404 | 1.74E-03 | 1.38E-01 | 1.40E-02 | 2.90E-01 | 3.68E-03 | 8.71E-02 | 4.92E-02 | 3.52E-01 |
| SLC9A7 | 4006841 | 2.65E-03 | 4.92E-02 | 2.03E-02 | 1.75E-01 | 1.61E-01 | 8.77E-01 | 1.80E-03 | 9.74E-03 |
| MAGEH1 | 3978760 | 3.25E-03 | 6.15E-02 | 2.38E-02 | 1.86E-01 | 4.99E-01 | 3.98E-01 | 7.32E-04 | 2.81E-02 |
| GPC4 | 4022370 | 5.00E-03 | 8.06E-03 | 3.50E-02 | 6.66E-02 | 1.56E-02 | 1.35E-02 | 3.81E-02 | 7.59E-02 |
| TSC22D3 * | 4017381 | 5.84E-03 | 1.11E-03 | 3.87E-02 | 1.83E-02 | 2.54E-02 | 2.28E-01 | 2.79E-02 | 4.79E-04 |
| EDA2R * | 4011096 | 6.02E-03 | 3.03E-03 | 3.87E-02 | 3.83E-02 | 1.12E-03 | 7.24E-04 | 6.51E-01 | 4.64E-01 |
| PIM2 | 4007617 | 6.61E-03 | 2.86E-02 | 4.08E-02 | 1.43E-01 | 8.22E-01 | 1.41E-01 | 9.91E-04 | 3.16E-02 |
| PDZD11 | 4011637 | 7.11E-03 | 1.48E-01 | 4.23E-02 | 2.97E-01 | 6.13E-02 | 3.29E-01 | 1.44E-02 | 1.03E-01 |
| Cxorf21 | 4003895 | 7.65E-03 | 2.83E-01 | 4.39E-02 | 3.88E-01 | 2.63E-03 | 8.27E-02 | 3.66E-01 | 9.73E-01 |
| OFD1 | 3969455 | 8.62E-03 | 7.52E-03 | 4.53E-02 | 6.66E-02 | 2.42E-01 | 1.50E-01 | 4.56E-03 | 6.28E-03 |
| CFP | 4007164 | 8.26E-03 | 1.56E-01 | 4.53E-02 | 2.99E-01 | 1.75E-03 | 5.47E-02 | 6.01E-01 | 6.58E-01 |
| LOC170082 | 3969396 | 8.75E-03 | 1.72E-01 | 4.53E-02 | 3.03E-01 | 6.34E-01 | 7.81E-01 | 1.77E-03 | 5.26E-02 |
| PIGA | 4000512 | 1.10E-02 | 2.76E-04 | 5.04E-02 | 7.43E-03 | 2.10E-02 | 1.79E-03 | 6.95E-02 | 1.33E-02 |
| GLA | 4015763 | 2.27E-02 | 1.52E-03 | 7.36E-02 | 2.34E-02 | 2.45E-02 | 1.67E-03 | 1.39E-01 | 9.33E-02 |
| PGK1 | 3982462 | 1.10E-01 | 1.67E-03 | 1.91E-01 | 2.35E-02 | 4.09E-02 | 2.50E-04 | 5.67E-01 | 6.89E-01 |
represents the 14 genes whose expression levels are significantly correlated with both carboplatin and cisplatin sensitivity (q-value<0.05) after a meta-analysis in the combined CEU and YRI samples, based on Affymetrix exon array data.
Bold: indicates that the gene expression level is correlated with sensitivity to both platinating agents (q-value<0.05) from a meta-analysis using the Affymetrix exon array data and is correlated with sensitivity to both platinating agents (p<0.05) from a meta-analysis (in the combined CEU, YRI and ASN data) using the Illumina array.
NA: not available.
CEU = Caucasian; YRI = Yoruba people from Ibadan, Nigeria; ASN= Asian.