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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: FEMS Microbiol Rev. 2011 Jan 19;35(3):475–497. doi: 10.1111/j.1574-6976.2010.00259.x

Fig. 7. PccB active site.

Fig. 7

(A) The binding pockets of acyl-CoA and biotin in PccB are perpendicular to each other and meet at the junction of the L-shaped active site. (B) The binding pocket of propionyl-CoA reveals that residue 422, at the end of the pocket, is the only residue different in AccB and PccB. (C) Sequence comparison of different CTs that accept propionyl-CoA as a substrate, like PccB, where position 422 (in PccB) is occupied by small residues (blue star), such as Asp or Cys, and CTs that accept acetyl-CoA as a substrate, such as AccB, where this residue is a larger, hydrophobic residue. Scoel (S. coelicolor), Seryt (S. erythraea), Mtub (M. tuberculosis), Hum (Human), Yeast, Svene (S. venezuelae), Tteng (T. tengcongensis).