Table 2.
Maximum percent Cocaine-Appropriate Responding (%CAR) Observed during Substitution Experiments with Cocaine, Amphetamine and Modafinil in a Group of Monkeys Trained to Discriminate 0.4 mg/kg Cocaine from Saline.
| Drug | Dose range tested (mg/kg; IM) | Maximum %CAR | # of monkeys substituting1 | N2 |
|---|---|---|---|---|
| Cocaine | 0.4 | 100 | 3 | 3 |
| Amphetamine | 0.032-0.1 | 100 | 3 | 3 |
| Modafinil3 | 3.2-18 | 100 | 2 | 4 |
| 32 | 75 | 1 | 2 |
1
Total number of monkeys in which the test drug produced ≥90% CAR.
2
Indicates total number of animals tested.
3
Data obtained 60 min following modafinil administration