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(A, B) Hippocampal neurons were transfected with the indicated plasmid combinations and scored after 2–3 d for mitochondrial morphology (A, live TMRM stain) or after 5–6 d for apoptosis (B, % transfected neurons with condensed/fragmented nuclei). Means ± s.e.m. of n = 3–6 experiments are shown. (C) Model summarizing effects of PKA/AKAP1 on mitochondrial shape and neuronal survival.
