Skip to main content
. 2011 Apr 19;9(4):e1001048. doi: 10.1371/journal.pbio.1001048

Figure 4. Auditory brainstem responses (ABR) in Eps8 mice.

Figure 4

(A–B) ABR thresholds, obtained from control (13 ears from 7 mice: circles and black line) and Eps8 knockout (16 ears from 8 mice: red squares and red line) adult mice. ABR thresholds for broadband click (A) and frequency-specific pure tone stimulation (B) in Eps8 knockout mice were significantly higher than those in control mice (click and noise pulse p<0.001; pure tone p<0.001 between 5.6 and 22.3 kHz). Note that for frequency-specific ABR, threshold could only be determined in 3 ears from knockout mice (no thresholds were determined in all animals for click stimulation). Thresholds of individual ears are shown as circle and square symbols (click) and blue lines (pure tone). Black and red lines give the mean values. Responses to pure tone stimuli in knockout mice could only be recorded at high stimulus levels outside the normal physiological range (B: pure tone threshold 110–120 dB SPL).