Table 4.
Tumor differentiation and budding, and expression of CD44 extracellular domain, MMP-7, laminin-5γ2, and sialyl LeX in invasive fronts
| n | Tumor budding (/cm) | CD44 | MMP-7 | Laminin-5γ2 | Sialyl LeX | |
|---|---|---|---|---|---|---|
| Sporadic cancer | ||||||
| Well differentiated | 30 | 206.7 ± 293.9 | 5.5 ± 2.8* | 4.2 ± 3.4 | 5.2 ± 2.7 | 3.2 ± 3.3 |
| Moderetely differentiated | 37 | 264.0 ± 240.6 | 5.1 ± 2.6 | 4.4 ± 3.4 | 5.7 ± 2.7 | 4.2 ± 3.1 |
| Poorly differentiated | 8 | 395.8 ± 280.5 | 6.6 ± 2.6** | 2.6 ± 2.9 | 4.6 ± 3.5 | 1.1 ± 0.8 |
| UC-cancer | ||||||
| Well differentiated | 6 | 146.2 ± 239.4 | 2.2 ± 1.5* | 3.8 ± 2.8 | 4.0 ± 2.6 | 1.3 ± 2.3 |
| Moderately differentiated | 4 | 157.0 ± 178.7 | 2.8 ± 1.5 | 4.7 ± 1.5 | 5.0 ± 1.2 | 1.0 ± 0.0 |
| Poorly differentiated | 5 | 145.8 ± 213.4 | 1.2 ± 1.6** | 1.0 ± 1.0 | 1.8 ± 2.0 | 1.4 ± 1.5 |
MMP - matrix metalloproteinase; n - number of cases; LeX - Lewis X; UC - ulcerative colitis.
* P = 0.010
** P < 0.001