Table 3.
Echocardiography values following cecal ligation and puncture (CLP) in BALB/C mice ± TEA. All echocardiograph values fell significantly at 8h following CLP ± TEA (12 or 50 mg.kg−1). Data shown as mean ± sem.
| Pre-CLP* (Time 0) (n=34) |
8 h post CLP* | |||
|---|---|---|---|---|
| No treatment (n=14) |
+ TEA 12 mg.kg−1 (n=10) |
+ TEA 50 mg.kg−1 (n=5) |
||
| Peak Velocity (m.s−1) | 0.85 ± 0.01 | 0.65 ± 0.02 | 0.69 ± 0.07 | 0.56 ± 0.06 |
| Stroke Volume (μl) | 45 ± 0.9 | 28 ± 0.9 | 32 ± 2 | 23.5 ± 1.8 |
| Heart Rate (bpm) | 544 ± 13 | 499 ± 13 | 475 ± 17 | 452 ± 12 |
| Cardiac Output (ml.min−1) | 24.6 ± 0.7 | 14.1 ± 0.8 | 15.9 ± 1.7 | 10.7 ± 1 |
| Cardiac Output.weight−1 (ml.min−1.mg−1) |
1.29 ± 0.05 | 0.7 ± 0.04 | 0.76 ± 0.08 | 0.57 ± 0.05 |
*
P < 0.001