Table 3.
APOE Genotype and APOE allele frequency by dementia status, with crude and adjusted prevalence ratios and 95% confidence intervals
| Dementia N(%) 273 |
No dementia N(%) 2247 |
Whole sample N(%) 2520 |
Crude PR (95%CI) |
Adjusted1 PR (95%CI) |
||
|---|---|---|---|---|---|---|
| APOE genotype | e2/e3 | 24 (8.8%) |
255 (11.4%) |
279 (11.1%) |
0.97 (0.64-1.46) | 0.96 (0.64-1.44) |
| e2/e4 | 2 (0.7%) |
15 (0.7%) |
17 (0.7%) |
1.33 (0.36-4.91) | 1.42 (0.37-5.45) | |
| e3/e3 | 162 (59.3%) |
1663 (74.0%) |
1825 (72.4%) |
1.00 (ref.) | 1.00 (ref.) | |
| e3/e4 | 77 (28.2%) |
285 (12.7%) |
362 (14.4%) |
2.40 (1.88-3.06) | 2.59 (2.04-3.28) | |
| e4/e4 | 8 (2.9%) |
29 (1.3%) |
37 (1.5%) |
2.44 (1.30-4.57) | 2.88 (1.58-5.27) | |
| p-value (Test for heterogeneity) | X2 = 54.6, 4 df p < 0.001 | X2 = 46.6, 4 df p < 0.001 | ||||
| Number of APOE e4 alleles | 0 | 186 (68.1%) |
1918 (85.4%) |
2104 (83.5%) |
1.00 (ref.) | 1.00 (ref.) |
| 1 | 79 (28.9%) |
300 (13.4%) |
379 (15.0%) |
2.36 (1.86-2.99) | 2.55 (2.02-3.21) | |
| 2 | 8 (2.9%) |
29 (1.3%) |
37 (1.5%) |
2.45 (1.31-4.58) | 2.90 (1.59-5.29) | |
| p-value (Test for trend) | X2 = 55.5, 1 df p < 0.001 | X2 = 41.8, 1 df p < 0.001 | ||||
| Any APOE e4 allele | 1 or 2 alleles | 87 (31.9%) |
329 (14.6%) |
416 (16.5%) |
2.37 (1.88-2.98) | 2.58 (2.06-3.22) |
| p-value | X2 = 53.0, 1 df p < 0.001 | X2 = 45.6, 1 df p < 0.001 | ||||
| APOE allele frequency | e2 | 0.048 | 0.060 | 0.059 | ||
| e3 | 0.778 | 0.860 | 0.851 | |||
| e4 | 0.174 | 0.080 | 0.090 | |||
| p-value (Test for trend) | X2 = 61.7, 1 df, P < 0.001 | |||||
1 Adjusted for age, sex and education - X2 derived from likelihood ratio tests