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. 2011 Apr 19;6(4):e18745. doi: 10.1371/journal.pone.0018745

Figure 1. Protein sequence alignments of the U-type pore and S4 regions with the NALCNs.

Figure 1

Regional protein sequences of the U-type channel from Lymnaea stagnalis (GenBank AAO85435 and AAO84496) were aligned with NALCN channel from Homo sapien (GenBank NP_443099) and Mus musculus (GenBank NP_796367), NCA-1 (GenBank NP_741413) and NCA-2 (GenBank NP_498054) from Caenorhabditis elegans, and α1U from Drosophila melanogaster (GenBank AY160083). Positive residues of the S4 region are highly conserved across different species. Pore forming sequence shows high degree of homology with a notable switch between the transmembrane domain II and III.